Children of The Night

Chapter Fourteen

Kate Neuman's home was in a high meadow six miles up Sunshine Canyon above Boulder. Kate had always disliked canyonsshe hated the lack of sunshine, especially in winter, and being at what she considered the mercy of gravity if any boulders decided to dislodgebut the road climbed out of the broad swale of Sunshine Canyon and ran along high ridgelines miles before it reached the turnoff to her home. She considered the location of her home almost perfect: high meadows laced with aspen and pine trees swept away. on either side, the snowcapped summits of the Indian Peaks section of the Continental Divide loomed up ten miles to the west, and at night she could look out the gaps in the Front Range south of the Flatirons and see the lights of Boulder and Denver.

She and Tom had bought the home the year before their breakup, and while they had used her income to secure the mortgage and pay the down payment, Kate would always be grateful to Tom for suggesting they look in that particular area for a house. The structure itself was large and modern but it blended into the rocks and trees of the ridgeline, its windows framed views in all four directions, there was a wonderful patio from which she could look downhill toward the Flatirons, and while there was only a handful of houses in the sixhundredacre residential ranch, the area was guarded by a security gate which could be unlocked only by the residents after a visitor contacted them via intercom. These visitors were usually shocked by the roughness of the gravel road beyond that security gate. The yearround residents there all owned fourwheeldrive vehicles to cope with winter snows at the seventhousandfoot level.

On this July morning one week after her discussion with Alan; Kate rose, jogged her usual threequarters of a mile on the loop trail behind her home, showered, dressed in her usual casual outfit of jeans, sneakers, and a man's white shirt for CDCshe wore a suit or dress only when a VIP visit or travel was inflicted on herand had breakfast with Julie and Joshua. Julie Strickland was a twenty-three-year-old graduate student who was currently working on her PhD dissertation on the effects of pollution on three species of flowers found only on the alpine tundra. Kate had met Julie three years earlier through Tom; the younger woman had traveled with Tom's Mountain Challenge Tours for an entire summer of hiking and camping above treeline in some of Colorado's most inaccessible regions. Kate was fairly certain that Julie and Tom had enjoyed a brief fling that summer, but for some reason the fact never bothered her. The two had become friends soon after meeting each other. Julie was quiet but enthusiastic, competent and funny. In exchange for watching Joshua five days a week, Julie had her own section of Kate's five-thousand-square-foot house, was free to use Kate's 386e PC with its CDROM memory for her thesis when Kate was at work, had weekends free for her field trips, and received a token salary that allowed her to buy gas for her ancient Jeep.

Both women enjoyed the arrangement, and Kate was already worrying about the winter when Julie would be finished with her dissertation. Always sympathetic to the plight of working mothers forced to scramble for daycare, Kate now had nightmares about finding adequate care for Joshua. But on this beautiful summer morning, the sun already high above the plains and free of the rim of foothills to the east, Kate put the worry out of her mind as she ate her bran flakes and fed Joshua his cereal.

Julie looked up from her section of The Denver Post. “Are you taking the Cherokee or the Miata to work this morning?”

Kate resisted a smile. She had planned to take the red Miata, but she knew how much Julie loved to drive the roadster down the canyon. “Mmmm . . . the Jeep, I think. Did you have any shopping to do before you dropped Josh off at CDC?”

At the mention of his name, the baby smiled and banged a spoon on his tray. Kate wiped a bit of excess cereal from his chin.

“I thought I'd stop by the King Soopers on Table Mesa. You sure you don't mind me driving the Miata?”

“Just be sure to use the baby seat,” said Kate.

Julie made a face as if to say, Of course I will.

“Sorry,” smiled Kate. “Maternal instinct.” She said it as a joke but instantly realized that this was precisely what prompted such obvious comments.

“Josh loves the convertible,” said Julie. She took her own spoon and pretended to eat some of the baby's cereal. Joshua beamed his appreciation. Julie looked at Kate. “You want him there right at eleven?”

“Approximately,” said Kate, glancing at her watch and clearing her dishes. “We have the MR equipment reserved until one, so it's all right if it's a few minutes after . . . .” She gestured toward Joshua's unfinished cereal. “Do you mind . . . “

“Uhuh,” said Julie, exchanging goofy expressions with the baby. “We like to eat together, don't we, Pooh?” She looked back at Kate, oblivious to the drop of milk on her nose. “This MR stuff won't hurt him, will it?”

Kate paused by the door. “No. It's the same procedure as before. Just pictures.” Pictures of what? she asked herself for the hundredth time. “I'll have him home in time for his nap.”

It was less fun driving the Cherokee down the winding canyon road than doubleshifting the Miata through the turns, but this morning Kate was so lost in thought she did not notice the difference. Once in her office she asked her secretary to hold all calls and put a call through herself to the Trudeau Institute in Saranac, New York. It was a small research facility, but Kate knew that it did some of the best work on effector mechanisms of cellmediated immunity relating to lymphocyte physiology. More than that, she knew its director, Paul Sampson.

“Paul,” she said when she had got past receptionists and secretaries, “Kate Neuman. I've got a riddle for you.” She knew that Paul was a sucker for puzzles. It was a trait that he shared with quite a few of the best medical researchers.

“Shoot,” said Paul Sampson.

“We have an eightandahalfmonthold infant found in a Romanian orphanage. Physically the child looks about five months old. Mental and emotional development seem normal. Physically we see intermittent bouts of chronic diarrhea, persistent thrush, failure to thrive, chronic bacterial infections as well as otitis media. Diagnosis?”

There was only the slightest hesitation. “Well, Kate, you said it was a riddle, so AIDS is out. And that would be too obvious given the Romanian orphanage. Something interesting, you say.”

“Yep, “ said Kate. On the greenbelt below her CDC window, a family of whitetailed deer had come out to graze.

“Was the workup done in Romania or here?”

“Both places,” said Kate.

“OK, then we have some chance of reliability.” There was a pause and Kate could hear the soft sound of Paul chewing on his pipe. He had given up smoking the thing almost two years earlier, but still played with it when he was thinking. “What was the T and Bcell count?”

“Tcell, Bcell, and gammaglobulin levels almost did not register,” said Kate. The data was in the file on her desk but she did not have to refer to them. “Serum IgA and IgM were markedly decreased . . . .”

“Hmmm,” said Paul. “Sounds like Swisstype SCID. Sad . . . and rare . . . but not too much of a riddle, Kate.”

She watched the deer freeze as a car came up the winding road to the CDC parking lot. The car passed; the deer returned to grazing. “There's more, Paul. I agree the symptoms seem to suggest Swisstype severe combined immunodeficiency, but the white blood cell count is also low . . .”

“What is the WBC count?”

“Less than three hundred lymphocytes/muone,” she said.

Paul whistled. “That is strange. I mean, he makes the so-called `boyinthebubble' case of SLID look tame. According to your description, this poor Romanian kid has three of the four types of SCIDSwiss type, SCID with B lymphocytes, and reticular dysgenesis. I don't think I've ever seen a child with more than one of the manifestations. Of course, SCID itself is rare, no more than twenty-five or so kids worldwide . . .” His voice trailed off from stating the obvious to silence. “Is there more, Kate?”

She resisted the urge to sigh. “I'm afraid so. The child shows severe adenosine deaminase deficiency.”

“ADA too?” interrupted the doctor on the other end of the line. She heard his teeth click on the stem of his pipe and imagined the pained expression on his face. “The poor little bastard has all four types of SLID. The symptoms usually manifest themselves between the third and sixth month. How old did you say he was?”

“Almost nine months.” Kate thought of the “birthday cake” Julie would be shopping for at King Soopers. They celebrated Joshua's “birthday” every month. She wished she had taken time to shop for the cake herself.

“Nine months,” came Paul's voice, obviously musing to himself. “I don't know how the little guy got that far. . . he won't be getting much older.”

Kate winced. “That's your prognosis, Paul?”

She heard fumbling sounds at the other end of the line and could almost see the rumpled researcher sitting up, setting his pipe on the desk. “You know I wouldn't make a prognosis without seeing the patient and the tests in person, Kate. But . . . my God . . . signs of all four of the SCID variations. I mean, if it were just the ADA it would be bad enough . . . Has there been a haploidentical bonemarrow transplant?”

“There's no twin,” Kate said softly. “No siblings at all. The orphanage couldn't find even the parents. Obviously no histocompatibility is possible.”

There was silence for a moment. “Well, you could still try ADA injections to restore some of the immune function. Also shots of transfer factor and thymic extracts. And there's the humangenetherapy work that Mulligan, Grosveld and the others are working on. They're having some real success in building some ADAdelivering retroviruses . . .” His voice trailed off.

Kate said what her friend would not. “But with all four types of SCID present, the chance of avoiding a killer germ while the gene therapy was building resistance would be . . . what, Paul? Too small to count?”

“My God, Kate,” said the researcher, “you know as well as I do that all it takes to bushwhack a SCID's kid is one infection . . . generalized chicken pox, measles with Hecht's giantcell pneumonia, cytomegalovirus or adenovirus infections, or our old buddy Pneumocystosis carinii . . . one good head cold and the child is gone. Their own proteinlosing enteropathy adds to the problem. It's like greasing a slide and then going down it on waxed paper.” He paused for breath, obviously upset.

Kate spoke softly. “I know, Paul. And I used to do that too.

“Do what?”

“Grease the slide on the playground and go down it on waxed paper. “

She heard him chewing on his pipe again. “Kate, are you working with this child . . . personally, I mean?”

“Yes.”

“Well, I'd put my hope on the genetherapy work being done and hope for the best. There's a lot of energy going into solving the ADA problem these days, and if you lick that, the Swiss type, B lymph, and reticular dysgenesis malfunctions can be attacked with more conventional immunological reconstructive techniques. I'll fax you everything we have on Mulligan's work.”

“Thank you, Paul,” said Kate. The deer had gone back into the pine forest when she was not looking. “Paul, what would you say if I told you that this child's symptoms were periodic?”

“Periodic? You mean varying in severity?”

“No, I mean literally periodic. That they appeared, grew critical, and then were beaten back by the child's own rebuilt system?”

This time the silence extended for almost a minute. “Autoimmunological reconstruction? WBCs rebuilt from zero? T and Bcell levels up? Gammaglobulin levels returned to normal? From a SCID child with three hundred lymphs/muone as a starting point? With no histocompatible marrow transfusions, no ADA retrovirus gene therapy?”

“Correct;” said Kate. She took a breath. “With nothing but blood transfusions.”

“Blood transfusions?” His voice was almost shrill. “Before or after diagnosis?”

“Before. “

“Bullshit,” said the researcher. Kate had never heard him use a curse word or vulgarity before. “Absolute bullshit. One, autoimmune reconstruction doesn't happen outside the comic strips. Two, any live vaccines or nonirradiated transfusions for this child prior to diagnosis would have almost certainly killed him . . . not brought about some miracle cure. You know the problems an allogenic transfusion would cause, Katefatal graftversushost disease, progressive generalized vacciniahell, you know what the result would be. There's something wrong with this picture . . . either a misdiagnosis on the Romanian end or a total screwup in the T cell study or something.”

“Yes,” agreed Kate, knowing that the data was valid.

“I'm sorry to take up your time on this, Paul. It's just that things seem a bit muddled.”

“That's an understatement,” came her friend's voice. “But if anyone can straighten it out, you can, Kate.”

“Thank you, Paul, I'll talk to you soon.” She set the phone in its cradle and stared out at the empty meadow.

She was still staring two hours later when her secretary buzzed to tell her that Julie was there with the baby.

Even after fifteen years as a physician, Kate thought that the saddest sight on earth was a small child surrounded by modem medical equipment. Now, as a mother watching her own child submit to sharp needles and frightening equipment, she found it twice as sad.

Julie had shown up weeping and apologizing. It took several minutes for Kate to understand that the girl had set Joshua loose in his baby seat for a moment in the front seat of the Miata“just while I put his birthday cake in that dinky little trunk”and the child had tumbled out, hitting his forehead against the center console. There had been little bleeding, Joshua had already stopped crying, but Julie was still upset.

Kate had calmed her, shown her how slight the abrasion wasalthough there was going to be a serious goose egg, and then led a small parade of Josh, Julie, Kate's secretary Arleen, her office neighbor Bob Underhillone of the world's top men on hereditary nospherocytic hemolytic anemiaand his secretary Calvin on a search for some antiseptic and a BandAid. Kate found it amusing, and even Julie began chuckling through her tears that there they were in the Rocky Mountain Region Center for Disease Control, a sixhundred-milliondollar research center containing stateoftheart medical laboratories and diagnostic equipment . . . and no Mercurochrome or BandAid.

Finally they found some sprayon antiseptic and adhesive strips in the chief administrator's officehe was a fanatic jogger who tended to fall down a lotCalvin brought a lollipop for Joshua, Julie left in a better mood, and Kate brought her baby down to the basement Imaging Center.

When the Center was being moved to the NCAR complex, Dr. Mauberlychief administrator and a PhD doctor in epidemiology, not a medical doctorhad opposed the presence of the magnetic resonance imagers in the same complex as CDC's pride and joy, the twin Cray computers on the second floor. Mauberly and the others knew that in the early days of MRimaging, faults in shielding had ruined wristwatches and stopped automobiles on the street outside. Or so the tales went. Dr. Mauberly wanted to take no chances with the Crays that represented a sizable chunk of RMCDC's budget.

Alan Stevens and the other technicians had convinced the administrator that the Crays' brains and cojones were in no danger from the MR and CT scanners; Alan had shown how the basement imaging complex would be electromagnetically isolated from the rest of the world, literally a room within a room. When Dr. Mauberly had still hesitated, Alan brought in the pathologists and ClassVI Biolab glamour boys. The MR and CT equipment might not be necessary for living patients, they pointed out, but it was absolutely vital for the corpsesboth human and animalthat were the raison d'etre of Pathology and Biolab's daily toil. Mauberly had agreed.

Alan met Kate in the basement hallway between the imaging and sealed lab centers. Joshua had been here before and was not afraid of it, although this time there was a nasty surprise as RN Teri Halloway was waiting in the imaging room with an i.v. tube and needle. Joshua wailed as the needle was inserted on the inside of his skinny arm. Kate tried not to wince. She would have handled the transfusion herself, but Teri had a gentler touch. Sure enough, Joshua quit crying after only a Pro forma protest and lay back blinking. Alan and Kate helped set him onto the imaging palette, setting his head firmly in place with pillows and strips of broad tape, also taping his wrists to the pillows. It was disturbing to see, but they could not run the risk of the baby turning and moving during the imaging sequence. Not only would it ruin the CT pictures, but it would dislodge the biosensors Teri was setting in place so they would monitor realtime physiological changes. Kate leaned over and cooed to Joshua during the entire preparation, having his favorite stuffed animala Pooh bear with one eye missingtalk and play with him. He barely seemed to notice when Teri pricked his finger for the first of many blood tests. The nurse nodded at Kate, smiled at Joshua, and hurried off to the adjoining lab.

Finally Kate tucked Pooh in next to her son and left the room. Airlockstyle doors slid shut behind her. She joined Alan at the bank of video monitors.

“Is his runny nose just from crying or have the flu symptoms returned?” asked Alan.

“The last three or four days,” said Kate. “The diarrhea's back, too.”

Alan nodded and pointed toward the biosensor readout. “His temperature is closing in on a hundred. And look at the results of the first test Teri took.”

Kate was looking. Data from the lab was fed directly through to the MR/CT control room. According to the first test, Joshua was showing the characteristic SCID shortage of white blood cellsthe WBC count was at 930 lymphocyte/ Rlas well as the classic drop-off in Tcell, Bcell, and gammaglobulin levels. More than that, liver enzymes were elevated and there were indications of an electrolyte imbalance.

“Look like GVH problems to me,” said Alan.

Kate tapped a pencil against her teeth. “Yes, except it's been almost a month since the last transfusion, and he showed no graftversushost rejection then. It's not the new blood his body has trouble with . . . it's his own system he seems to want to reject.” She glanced at the monitor. Joshua seemed frail and insignificant strapped into his imaging cradle. She could see his mouth move as he cried, but there was no sound. Kate switched on the audio pickup and keyed the microphone so that he could hear her. “It's all right . . . Mama's right here . . . It's all right.”

She nodded at Alan. “Let's do it and get him out of there.”

Alan's fingers played the console as if it were a Wurlitzer keyboard. Joshua's imaging palette slid him into the CT torus, and Kate had the surreal sense that he was a tiny, human artillery shell being loaded into the breech of a plastic cannon. She watched as the display showed that the i.v.drip had been opened to the whole blood, then as the biosensors began to relay Joshua's body's response to it. Threedimensional images of his liver, spleen, and abdominal lymph nodes began to build up on the monitors.

“To do this right,” said Alan, his eyes moving from monitor to monitor, “we should scan his spleen using 99mTc colloid or heatdamaged red blood cells so we could get a detailed fix on any functioning splenic tissue.”

“Too invasive,” snapped Kate. Her eyes stayed glued to the biosensor columns. “We'll stick to the CT, MR, and ultrasound,” she added, her voice softer. “I don't want him to go through any more than he absolutely has to.”

Alan nodded agreement. “OK,” he said, “coming up to the scan of stomach wall . . . right . . . here. “

Kate leaned over, stared at the central monitor, and frowned. “I don't see the abnormality we found last time.”

“The CT can't pick up anything less than two centimeters,” said Alan. “At this point we're dealing with a slightly fibrous mass, smaller and less dense than most tumors. Ultrasound isotopic imaging with 67Ga and “111Inlabeled leukocytes would show it was something worth worrying about, but the CT just gives us the slightest indication of an abscess . . . there, see that shadow?”

Kate did, but only because Alan's finger tapped the monitor at the precise spot. It was the shadow of a shadow. She looked back at the biosensor columns.

“My God,” she whispered, “his temperature is at a hundred and three and rising. Stop the sequence, I've got to get in there.”

Alan grasped her forearm. “No, wait . . . I've got a hunch on this, Kate. We weren't monitoring his temperature last time, just taking pictures. My guess is that whatever's going on with the redistribution of blood to that shadow organ in his stomach wall, it's burning up lots of energy.”

“It's burning him up,” said Kate. “Abort the sequence.”

Alan set his hand above the red master switch, but then raised it and pointed. “Look.”

Joshua's temperature now hovered at 103.5, but the other sensors showed near chaos. His blood pressure spiked, normalized, then spiked again. His heart rate was fifty percent over normal. Skin resistance traced a mountain range of changes.

Kate leaned over the console, her mouth open. “What's happening?”

Alan pushed his glasses higher on his snub nose and pointed to the primary monitor.

The shadow on Joshua's stomach wall had materialized into a veinandcapillaryrich mass. The CT scan showed a nexus of nerves that was almost three centimeters across and growing.

“He's stabilizing,” said Alan, voice tense.

Kate saw that he was right. Temperature, blood pressure, heart rate, and the other vitals were dropping back into the normal range.

“We're finished with the first sequence,” said Alan. The monitor showed the palette sliding out. Joshua was squirming a bit within his restraints, but showed no signs of trauma or discomfort. He was not crying. Alan looked at Kate over the tops of his glasses. “Do you want to go in with Teri for the next round of blood and pictures or shall we scrub this right now?”

Kate hesitated only a second. The mother in her wanted to lift her son out of that torture device now . . . take him home now. The doctor in her wanted to find out what was trying to kill him, and find out now.

“Call Teri,” she said, already heading for the airlock. “Tell her I'll help her draw the next blood sample.”

The three imaging sequences took less than fifty minutes. Joshua had wet his diaperthey'd had a catheter rigged for urine samples but it had overflowedbut other than that and a lot of rage at being restrained for so long, the baby seemed fine as Kate lifted him out and rocked him while Teri and Alan helped detach the biosensors. Teri took the last blood sample, pricking Joshua's big toe again, and the small room echoed to his wails.

As they left the imaging complex, Alan said, “I'll program the entire sequence to deal with different variables and have the enhanced videotapes ready to roll by eight A.M. Shall I start with Tcell rate or the adenosine deaminase curve?”

“Do the AD,” said Kate. “But I want it visually all cross-referenced.”

Alan nodded and made a note on a small pad.

“We'll have all the lab data back by six P.M.,” said Teri. “I'll make sure McPherson handles it personally.”

Kate used her free hand to pat the nurse's shoulder.

“Oops,” said Teri. Joshua's BandAid had been loosened from rubbing against his head restraints. Teri pulled it free. “Well, I guess we don't need this old thing, do we, sweetums?”

Alan caught Kate's hesitation and sudden attention. “What?” he said, some concern in his voice.

Kate made sure that her voice was calm and level. “Nothing. I was just hoping that this doesn't screw up his nap schedule.”

Swinging him around slightly, bringing out the first smile of the afternoon, Kate brought her son's forehead closer to the overhead light. She leaned closer and kissed him, her eyes only inches away from the sweetsmelling skin of his scalp.

The nasty bruise and abrasion he'd received less than two hours before were gone. No pooled blood under the skin, no sign of swelling or lingering hematoma, not the slightest sign of the raspberry rash that should have taken a week or two to fade.

The wound was gone. As if it never existed.

“This should be fascinating stuff,” said Alan, returning to his console. “I can hardly wait.” “Me too,” said Kate, looking into the baby's eyes and realizing that her heart was pounding wildly against her rib cage. “Me too.”